The loss of a pregnancy during the first 13 weeks is called “early pregnancy loss,” “miscarriage” or
“spontaneous abortion.” Early pregnancy loss occurs in about 10% to 15% of known pregnancies.
Most early pregnancy losses result from an abnormal embryo (the earliest stage of the baby’s development), not by anything related to the mother or father.
In at least half of the cases, early pregnancy loss is caused by an abnormal number of chromosomes
in the embryo. In this instance, the egg or sperm that makes the embryo has the wrong number of
chromosomes. This is a random event. Having it happen in one pregnancy does not mean that a
couple is at high risk of having it happen in future pregnancies. Other causes of early pregnancy loss
involve other embryo problems, including missing genes, extra genes or other abnormalities.
It’s Not Your Fault
It is natural for a mother who has experienced an early pregnancy loss to think she did something to
cause it. She will often search her memory to find something she did, something she ate, medicine she
took or medication she forgot to take just before the loss happened. The loss likely had nothing to do
with the mother but involved an abnormal embryo.
Recurrent Early Pregnancy Losst.
Most experts define recurrent loss as two or more losses in a row. After one early pregnancy loss, the
chance of another loss is about 15%, the same likelihood for someone who has not had a loss. Women
with two losses in a row have a slightly higher chance of having another loss, about 20%. After three
early losses in a row, the risk of a loss in the next pregnancy is about 30%.
As with single losses, most cases of recurrent loss are caused by abnormalities of the embryo, not by
anything concerning the mother or father. However, with recurrent losses, there is a higher chance of
finding specific problems in the parents. Therefore, an evaluation, or “workup,” is reasonable if you
have had two or more losses in a row.
Components of the standard workup for recurrent early pregnancy loss include patient history,
chromosome testing and antiphospholipid antibody testing.
Patient History
Your physician will review each previous loss with you, including any symptoms you had, findings from
ultrasounds, prior procedures (D&C or medical induction), lab results (chromosome testing, pathology
studies, blood testing) and gestational age when the loss occurred. Other aspects of the history may
include whether you have regular menstrual cycles, prior surgeries of your uterus or cervix, exposure
to toxic chemicals, a history of blood clots in the legs or lungs or any family history of recurrent miscarriages in close relatives.
Chromosome Testing
Sometimes, one parent has a chromosome abnormality that produces no findings in the parent but
can cause a high pregnancy loss rate. Chromosome testing of both parents is recommended as part
of the workup for recurrent pregnancy loss.
Antiphospholipid Antibodies
Some women have antiphospholipid antibodies (detected through blood tests) that can cause pregnancy loss and produce blood clots. If the antibodies are present and they persist for more than six months, treatment with an anticoagulant (blood thinner) and aspirin may reduce the chance of recurrent miscarriage.
Additional Testing
Your doctor may recommend additional tests to detect:
Anatomical problems, such as an abnormally shaped uterus or fibroids or polyps inside the uterus that may prevent an embryo from implanting normally.
Thyroid disorder because women with low thyroid hormone levels or certain thyroid antibodies (TPO autoantibodies) can have recurrent miscarriages.
Diabetes — High blood glucose levels (as reflected by high levels of A1C) in early pregnancy can cause miscarriage or birth defects.
Immune testing and treatment — Some specialists order blood tests for natural killer cells and other immune components, but the American College of Obstetricians and Gynecologists and the American Society of Reproductive Medicine do not recommend such evaluations because treatment of immune problems has not been proven to improve the chances of success in the next pregnancy.
Problems with ovarian reserve, meaning a limited ability of the ovary to produce healthy egg cells capable of fertilization.
Treatment of Recurrent Early Pregnancy Loss
If the workup reveals a specific abnormality that can be treated, treatment of the abnormality is usually considered. However, in most cases, no abnormality is found on the workup because most cases of pregnancy loss are caused by abnormalities of the embryo, not abnormalities in the parents. If no abnormality is found, there is no need for treatment. Even without treatment, pregnancy success rates of about 80% are found in mothers with two pregnancy losses in a row and 70% in mothers with three losses in a row.
Maintain your normal schedule of exercise and healthy activity. The Society for Maternal-Fetal Medicine does not recommend routine activity restriction for FGR.
Call your health care provider if the fetus doesn’t seem to be moving as much as usual.
How Does FGR Affect Your Baby’s Future Health?
Most babies catch up in their growth after birth and go on to have normal lives.
There may be an increased risk of certain problems after your child becomes an adult (heart disease, high blood pressure, stroke and diabetes).
This is an active area of research. Ask your pediatrician if your child needs any special testing or follow-up care.
How Does FGR Affect Your Future Health?
FGR may mean an increased risk of metabolic syndrome, a cluster of conditions that occur together, such as:
High blood pressure
Heart disease
Stroke
Type 2 diabetes
Excess body fat around the waist
Abnormal cholesterol and triglyceride levels
Tell your primary doctor that you had a baby with fetal growth restriction and ask whether you
should have annual testing for metabolic syndrome.
You can reduce your risk by:
Breastfeeding for one to two years, if possible (breastfeeding lowers your risk of diabetes, high
blood pressure and heart disease)
Avoiding tobacco, vaping products, alcohol and recreational drugs
Staying active and exercising five days a week
Eating a healthy diet
Aiming for a healthy body weight
Can You Decrease the Chances of Having Another Baby with FGR?
The chance for FGR in future pregnancy is about 25% (one out of every four pregnancies).
The chance may be higher if you have certain illnesses (e.g., lupus or high blood pressure).
Before Your Next Pregnancy
Quit using tobacco, vaping products, alcohol, marijuana and illicit drugs.
Discuss with your doctor if you have any chronic health conditions (high blood pressure, diabetes, lupus or other autoimmune disorders).
Review with your doctor all medicines you take (both prescription and over-the-counter).
Take a prenatal vitamin daily containing folic acid (800 mcg) before you get pregnant.
Eat a healthy diet, exercise and aim for a healthy body weight.
During Your Next Pregnancy
Attend regular prenatal visits to check on blood pressure and fetal growth.
Ask your doctor whether extra ultrasounds are recommended to check fetal growth.
Ask your doctor whether you should take low-dose aspirin.
Fetal urinary tract dilation occurs when the tubes that carry urine from the kidneys to the bladder become wider than they should be. These tubes are the “renal pelvis” and the “ureter” tubes. Imagine a water hose that’s a bit bigger than usual. This happens in about 1 out of every 50 pregnancies. The good news is that it often resolves on its own. Other terms sometimes used for urinary tract dilation are UTD, pyelectasis, pelviectasis and hydronephrosis.
What Causes Fetal Urinary Tract Dilation?
The exact cause isn’t always clear. Some common causes include:
Baby making more urine than usual
Urine that refluxes up from the bladder rather than going out through the urethra
Narrowing of the ureter or urethra
What Are the Signs and Symptoms?
There are no noticeable signs or symptoms of fetal UTD during pregnancy. It is usually detected during routine ultrasound examination.
What Can Parents Do?
During pregnancy, a follow-up ultrasound about two months before the due date is usually recommended. In about three out of every four babies with mild UTD, the findings will be normal at the follow-up exam, and no further follow-up is needed.
If dilation is still found at the follow-up exam, another ultrasound after the baby is born will be recommended. It is important that you tell the baby’s doctor about the UTD finding so that the ultrasound can be ordered.
Keep your scheduled appointments for prenatal visits, lab tests and ultrasound exams.
How Is UTD Treated?
In most cases, fetal UTD resolves on its own without special treatment, either before the baby is born or during the first year or two after birth. In a few cases, the baby’s doctor will recommend an antibiotic to prevent kidney infection. In a few cases with moderate or severe dilation, the doctor will recommend placing a stent (plastic tube) in the ureter tube to help it drain better. In rare cases, other procedures may be recommended.
Will My Baby Be Okay?
Most babies with UTD have normal kidney function and normal lives. Severe cases may result in some degree of kidney damage, but this is very uncommon. Most often, UTD is an isolated finding and is not associated with any other abnormalities or problems with child development. In a few cases, the ultrasound or genetic tests may reveal other problems, which your doctor will discuss with you.
Diabetes is a disease that happens when too much sugar is in the blood. There are many kinds
of sugars in our bodies. The sugar we talk about most often is glucose. Everyone needs a certain
amount of glucose in the blood. However, too much glucose is harmful and can cause many serious
problems, such as gestational diabetes, during pregnancy.
Why Did I Get Gestational Diabetes?
Anybody can get gestational diabetes caused by pregnancy hormones that raise the amount of
glucose in the blood. Several factors increase the risk of getting gestational diabetes, including:
Age 25 years or older
Obesity
African-American, Hispanic, Asian, Pacific Islander or Native American background
Prior pregnancy with gestational diabetes or delivering a baby with a birth weight of 9 pounds or more
Family history of diabetes or gestational diabetes
Pregnancy with more than one fetus (e.g., twins, triplets or more)
Inactive lifestyle
High blood pressure or heart disease
Polycystic ovarian syndrome
While these are the most common risk factors, you can get gestational diabetes even if you don’t
have any of the risk factors.
Why Is Gestational Diabetes Important?
Glucose in the mother’s blood feeds the fetus (unborn baby). If there is too much glucose, the fetus
gets fed too much. High amounts of glucose can cause the fetus to grow too large, resulting in:
Increased chance of Cesarean delivery (C-section)
Risk of birth injury during vaginal delivery
Risk of jaundice in the baby or other complications requiring intensive care
After delivery, the baby stops getting glucose from the mother. Therefore, glucose levels can fall too
low. Babies born too large after a gestational diabetes pregnancy have a higher chance of:
Diabetes during childhood
Obesity during childhood
These problems can have life-long harmful effects on the child, which are preventable by keeping
your blood glucose levels stable during pregnancy.
What Can I Do to Prevent Harm to My Baby or Myself?
Most people with gestational diabetes can keep glucose levels normal with three simple changes:
Eating right to prevent blood glucose from going too high
Walking for 10 to 20 minutes after each meal
Checking blood glucose levels often
Eating Right
Many foods do not raise blood glucose too high. We recommend eating three healthful meals each
day, with a healthy snack between meals. Small meals do not increase your glucose as much as large
meals. A snack between meals and at bedtime will help you feel full, so you can eat smaller meals.
We want you to continue gaining weight during your pregnancy. Weight loss during pregnancy is
not our goal. Some carbohydrates (starches) are recommended with each meal and snack. It is not our goal to have you avoid all carbs. Keep a written record of what you eat and when you eat.
Activity After Meals
Walking 10 to 20 minutes after each meal will help blood glucose levels. If you have been told not to walk, arm exercises can be done instead.
Blood Glucose Monitoring
Checking glucose levels will help you learn which foods work for you and which do not. Check your
glucose as soon as you get up each morning (fasting). Check your glucose after each meal (set a timer
as a reminder). That’s a total of four checks each day: fasting and after every meal. Keep a written record of your blood glucose values/levels. To prevent the fetus from growing too large, it is best if glucose values are:
Usually less than 95 before breakfast (fasting)
Generally less than 140 at one hour after meals or less than 120 at two hours after meals
It is OK if you go a little over these numbers occasionally. If you go over by a lot, try to figure out what
you ate that made your glucose go high and avoid eating that again. If your glucose level is over 250,
call your diabetes prenatal care provider for further advice.
Medication
If your glucose level remains high after eating right and getting the right amount of activity, your
provider may prescribe medication to help lower your glucose level.
Will Gestational Diabetes Go Away After Pregnancy?
For most people, gestational diabetes goes away after pregnancy. However, people with gestational
diabetes are likely to get it during future pregnancies. Additionally, people with gestational diabetes
have a high chance of getting diabetes later in life. Therefore, you should get tested one to three
months after pregnancy to see if you have diabetes or prediabetes.
Tell your primary doctor that you have had gestational diabetes and get yearly check-ups.
Healthful Food Choices for Gestational Diabetes
Lean proteins are needed for fetal growth and help you to feel full.
Good options include: poultry (chicken, turkey), eggs, fish, greek yogurt, lean red meats (beef, pork), nuts and seeds, legumes (beans, lentils, soy products).
Non-starchy vegetables provide vitamins, minerals and fiber, including:
Broccoli, cucumbers, green beans, onions, peppers, salad greens.
Healthful fats help you to feel full and provide energy.
Complex carbohydrates (carbs or starches) provide energy, fiber
and some nutrients.
Good choices include: beans and lentils, berries, brown rice, sweet potatoes, whole grain crackers, low-fat dairy (milk, cheese).
Foods to Avoid With Gestational Diabetes
Simple carbohydrates are foods that are high in sugar or foods with starches that your body converts rapidly to sugar, including:
Sugary beverages (juices, sodas), white rice, white flour (bread, tortillas, roti, cakes, pastries), potato (baked, mashed, French fries, chips), cereals, jams and jellies, honey, sugar added to coffee, tea or other drinks, desserts, sauces and condiments that contain hidden sugars (barbecue sauce, ketchup, teriyaki, syrups, some salad dressings and many others).
Sometimes, glucose values return to normal. Sometimes, they appear normal for a while but
then increase again later. Sometimes, they don’t ever completely return to normal.
Up to one in every three women with GDM (30%) will have prediabetes during the first
year after delivery.
Up to one in every two women with GDM (50%) will have Type 2 diabetes within 10 years.
What Do I Need To Do After a Pregnancy With GDM?
Before leaving the hospital, ask your health care provider whether you should continue fingerstick
glucose testing or continue any diabetes medicines.
Make an appointment to see your OB provider for routine care and a follow-up visit, including
screening for depression and discussing contraception (birth control) options.
Make an appointment for a glucose tolerance test (GTT) between four to 12 weeks after delivery
to determine if you have prediabetes or diabetes. Arrive at the lab after fasting for at least eight
hours (water only). Two blood samples will be taken. The first sample is taken while you are
fasting. Then you will have a glucose drink, and then blood is drawn again two hours later.
How Can I Decrease My Chances of Getting Diabetes In Future Years?
Lifestyle choices have health benefits for all people who have just delivered a baby, whether or
not you have prediabetes:
Breastfeed — This helps your body use extra calories stored during pregnancy, which helps
you lose weight.
Aim for a healthy weight — You usually lose 10 to 15 pounds with childbirth. After that, aim
for 1 pound per week.
Exercise — Aim for 30 minutes, five days per week. Walking outdoors is an excellent form of
exercise. Do the best you can!
Eat healthful foods (see the Balanced Diet section below).
If you have prediabetes
Lifestyle choices listed above will delay or prevent the progression from prediabetes to
diabetes.
Referral — We will refer you to a primary care provider to develop a plan to lower the chance
you will get diabetes in future years. We recommend that you get checked for diabetes
yearly.
Medicine — Certain oral medications may provide additional benefits in preventing the
development of diabetes. They are taken by mouth, not an injection like insulin. Your primary
care doctor may start you on oral medicine.
A balanced diet and healthy hints
Eating well means eating healthy foods that give you the nutrition you need in the right amounts.
You don’t have to give up your favorite foods completely.
Have a balance of proteins, fats and carbohydrates.
Get tips, ideas and a personalized plan using the Choose My Plate program from the U.S. Department of Agriculture (ChooseMyPlate.gov).
Plan meals ahead of time and stick to the plan.
Add lemon slices to water instead of drinking juice and sugary drinks.
Use smaller containers for food and drinks.
Keep fruit and cut vegetables handy for snacks.
Use the stairs instead of the elevator.
Park farther away from building entrances and walk the extra distance.
Don’t go to the grocery store hungry.
Before Your Next Pregnancy
Wait at least 18 months before you get pregnant again. Shorter intervals may have an increased risk of miscarriage or preterm birth. Use a reliable method of contraception (birth control).
Take a prenatal vitamin daily. Folic acid in these vitamins helps prevent some types of birth defects.
Ask your doctor if you should have an A1C test or repeat GTT before you become pregnant.
If you have prediabetes or Type 2 diabetes, you can decrease the risk of miscarriage or birth defects by having your blood glucose in good control before you get pregnant. Ask about our preconception diabetes care program.
Life-Long Health
People who have had GDM have higher chances of developing health problems, such as high blood pressure, heart disease or stroke, sometimes years or decades after pregnancy. To reduce the likelihood of these problems:
Maintain a healthy weight
Exercise regularly
Eat healthful food
Blood pressure should be checked at least once a year. If you get high blood pressure, follow your provider’s treatment advice and check your blood pressure more often.
Tell your primary care provider that you have had gestational diabetes and ask if you should be tested yearly to check A1C, cholesterol and triglycerides.
Why Would I Take Low-Dose Aspirin During Pregnancy?
Low-dose aspirin is used to lower the chances that you will get a disease called preeclampsia.
Preeclampsia is a serious pregnancy complication that includes very high blood pressure and other problems.
People with certain risk factors for preeclampsia will benefit from low-dose aspirin.
Aspirin started during the second trimester of pregnancy reduces the chances of getting preeclampsia during the third trimester by about 15%.
Do I Have Risk Factors?
High risk level
Preeclampsia in a prior pregnancy
Twin or triplet pregnancy (or more)
Chronic hypertension
Diabetes
Kidney disease
Autoimmune disease
Moderate risk level
No prior delivery
35 years or older
Obesity
In vitro fertilization (IVF)
Your mother or sister had preeclampsia
African-American ethnicity
Previous child with low birth weight
You were born with low birth weight
Low income
More than 10 years since your last delivery
Who Recommends Using Low-Dose Aspirin?
The American College of Obstetricians and Gynecologists (ACOG) and the United States Preventive
Services Task Force (USPSTF) both recommend that low-dose aspirin should be taken by patients
who have:
Any high-risk factor
More than one moderate-risk factor
What Dose of Aspirin Is Recommended?
The only dose labelled as “low-dose aspirin” in the United States is 81 mg.
Both ACOG and USPSTF recommend one tablet daily.
Some doctors recommend two tablets daily (162 mg).
Doses of 50, 75 or 100 mg are available in other countries.
If you have any of these doses, ask your doctor which dose is right for you.
Which Type of Low-Dose Aspirin Is Best to Take During Pregnancy?
Any brand of low-dose aspirin sold in the United States is fine. The FDA requires all
manufacturers to meet the same strict standards to guarantee purity and potency.
It is not known whether “enteric-coated aspirin” is better. The coating is intended to prevent
stomach irritation, ulcers and heartburn. However, the coating may also reduce the effectiveness
by reducing the amount of aspirin absorbed by your body.
When Should I Start Low-Dose Aspirin?
The best time to start low-dose aspirin is at 12 to 16 weeks of pregnancy.
If you are already past 16 weeks, you may start it at any time.
You may take aspirin at any time of day. It is best to develop a pattern of taking it at the same
time every day. For example, take it when you take your prenatal vitamin.
Do I Need a Prescription?
No prescription is needed.
Over-the-counter low-dose aspirin should cost less than $10 for a bottle of 200 tablets, enough
to last your entire pregnancy.
Can I Wait Until I Show Signs of Preeclampsia to Start Aspirin?
No. Low-dose aspirin is used to prevent preeclampsia, not to treat it.
Aspirin has no benefit once preeclampsia appears.
To be effective, aspirin must be started during the second trimester and best before 16 weeks.
What If I Miss a Dose?
If you miss a day, just resume taking daily aspirin the next day.
There is no reason to double-up the dose the next day.
Don’t miss too many doses. Aspirin is much less effective if you miss more than 10%
(1 of every 10).
When Should I Stop Low-Dose Aspirin?
Aspirin may be continued throughout pregnancy.
Some doctors recommend stopping once you reach 37 weeks.
Are There Any Other Benefits of Low-Dose Aspirin?
Yes. In addition to reducing the chances of preeclampsia, clinical trials have shown that
aspirin also:
Reduces the chance of a preterm birth by about 20%
Reduces the chance of a growth-restricted baby (small for gestational age) by about 20%
Reduces the chances of perinatal death (stillbirth or newborn death) by about 20%
Is Taking Low-Dose Aspirin Safe?
Low-dose aspirin (81 mg daily) is safe for you and your fetus (unborn baby).
It has been used safely in tens of thousands of pregnancies without increased bleeding,
miscarriage or birth defects.
Are There Any Cautions About Using Low-Dose Aspirin During Pregnancy?
Make sure your doctor knows about all other medications you are taking.
Aspirin is not recommended for people who are allergic to aspirin or related medications,
such as ibuprofen.
Aspirin allergy can occur in anyone, but it is more common in people who have had
nasal polyps, asthma and hives.
Seek urgent medical attention if you have signs of an allergic reaction, such as
unexplained wheezing, rash or swelling of the lips, face or body.
Let your doctor know if you have bleeding while taking aspirin. They may recommend
stopping aspirin temporarily.
Some people get mild indigestion after taking aspirin. Taking aspirin with food may help
prevent indigestion.
Low-dose aspirin is not recommended for people who do not have any risk factors for
preeclampsia.
Aspirin Is NOT for Babies!
You may hear people use the words “baby aspirin” to describe low-dose aspirin.
There is no medication in the United States labelled as “baby aspirin.”
Aspirin in any dose can be dangerous for children and should not be given to a baby, child
or teenager without your doctor’s consent.
Even if aspirin is flavored, chewable or liquid, it does not mean it is intended to be given to
babies.
Low-dose aspirin is for adults only.
You should find low-dose aspirin in the adult section of the pharmacy, not the children’s
section.
Do not substitute children’s Tylenol (acetaminophen) or other children’s medicine for low-dose
aspirin. Only low-dose aspirin prevents preeclampsia.
Periviability, also called borderline viability, is the earliest stage of pregnancy when a baby can be born
and survive.
Types of Preterm Birth
There are two types of preterm birth — spontaneous and indicated.
Spontaneous Preterm Birth
“Spontaneous” means the birth process started naturally for reasons such as:
When the body naturally goes into labor prematurely
When the mother’s water breaks, called rupture of membranes (ROM)
When cervical insufficiency is present, called silent cervix dilation
Spontaneous birth often cannot be stopped, even with medication or surgery.
Indicated Preterm Birth
“Indicated” means that your physician has recommended delivery even though you are early in
pregnancy because continuing the pregnancy is not safe for you or the baby. Some situations for
indicated preterm birth include:
Medical conditions of the mother (severe high blood pressure, diabetes, obesity)
Severe fetal growth restriction
Placenta previa (the placenta partially or completely covers the cervix opening)
Severe uterus bleeding
Abnormal fetal heart rate patterns
Prior surgery of the uterus (C-section, fibroid removal)
Fetus with a high risk of death if the pregnancy continues
Infection of the baby or the uterus
Other serious illnesses of the mother or baby
Can Preterm Birth Be Stopped?
Your care team will do everything possible to prevent preterm birth. However, sometimes we cannot
safely delay delivery despite our best efforts.
What Is My Delivery Plan?
Timing of Delivery — Unless you choose to deliver now, we will try to prolong your pregnancy if it
is safe to do so. It is difficult to determine exactly when delivery will occur.
Steroid Medication — Injections are given one to seven days before birth to help improve the
baby’s chance of survival and reduce many health problems if the baby has reached a “viable” age.
We will recommend steroids if we think there is a chance the baby will be born during the next
seven days.
Method of Delivery — You can often have a vaginal delivery if the baby is head first and the fetal
heart rate is normal. A Caesarean delivery (C-section) is not required just because the baby is
premature.
A C-section may be considered for maternal reasons (to benefit the mother), such as a prior
C-section, bleeding or uncontrolled blood pressure. A C-section may also be considered for fetal
reasons (to benefit the baby), such as if the baby is not head first or the fetal heart rate is abnormal.
Although a C-section for fetal reasons may give the baby better chances, it does not guarantee that
the baby will survive or be able to sustain life.
A C-section carries serious risks for the mother, including infection, bleeding and a possible need for
a C-section in future pregnancies. Therefore, it will only be performed if there is a reasonable chance
it will benefit the baby or mother.
Will My Baby Survive If Born This Early?
The chances of survival depend on many factors, including gestational age, birth weight, the reason
for delivery and whether you have had steroid shots before delivery.
A neonatologist (specialist in the care of newborn babies) will visit with you about your baby’s
overall health based on the information we have about your pregnancy. However, we cannot predict
whether an individual baby will survive. Some babies thrive even when the chances are low, and
some do not survive even when the chances are high.
If My Baby Survives, Will He or She Be Normal?
Some extremely preterm babies survive “intact,” meaning they have no permanent damage even
though they were born extremely early. However, many extremely preterm babies develop serious,
permanent complications, including vision loss, hearing loss or damage to portions of the brain,
leading to physical disabilities, learning difficulties or profound impairment with a life-long need for
full-time care.
Every baby’s outcome is different. A pediatric neonatologist can visit with you about your baby’s
chances of surviving without any of these problems based on the gestational age at birth, the
estimated fetal weight and various other factors. However, we cannot say whether an extremely
preterm baby will develop and thrive like a full-term baby.
What Choices Do I Have Before My Baby Is Born?
When facing the chance of an extremely preterm birth, parents have some important decisions
to make.
The first choice is whether to:
Try to prolong the pregnancy as long as possible, even though it may not be possible to
gain much time, and the baby may still be born extremely early.
End the pregnancy by inducing labor, recognizing that the baby likely will not survive.
If you decide to continue the pregnancy, the next choice is whether you will consider the baby
viable, meaning that you think the chances of survival are high enough to make it worthwhile
to allow interventions, such as a C-section or cardiopulmonary resuscitation (CPR) to improve
the baby’s chances.
Some information that may help with your decision-making includes:
Before 22 weeks, babies are typically not viable and are not likely to survive.
At 23 to 25 weeks, we ask for your input on whether to consider the baby viable.
If the baby is considered viable, you will probably want fetal heart rate monitoring to
assess the baby’s well-being. You will probably also allow a C-section if needed for fetal
reasons.
After 25 weeks, most babies are viable and more likely to survive.
If the baby is not considered viable, there is no reason to do interventions, such as fetal
heart rate monitoring or a C-section.
What Choices Do I Have After My Baby Is Born?
If the baby is born alive, the next choice is whether to:
Request all possible treatments to keep the baby alive, including CPR, inserting a
breathing tube and using a breathing machine (life support), even if these efforts might
not work.
Select some of these treatments, but not all.
Select comfort care, meaning you request that the baby not have heroic treatments and
life support, allowing the baby to die naturally. We will do our best to keep the baby
comfortable during this process.
There are no clear right or wrong answers to these choices. The decision depends on your
values, beliefs and desires as you consider the pros and cons of having a baby that:
May not survive
May survive but be severely impaired
Might survive intact
Your doctors can provide information to help you make these choices, but they cannot make
the choices for you. You might make one set of choices now but then make different choices in
the coming days or weeks as gestational age increases
Health care providers use many words to describe different types of high blood pressure diseases. Following are some of the most common terms. This handout is mainly concerned with hypertensive diseases of pregnancy, but some of the contents are also relevant for chronic hypertension.
Transient or non-persistent high blood pressure: A single blood pressure measurement is high, but repeat measurement is normal
White coat syndrome or white coat hypertension: Blood pressure is high in the physician’s office or other clinical settings but normal at other times
Hypertension: High blood pressure on more than one measurement, either on different days or at least several hours apart
Chronic hypertension: Hypertension that was present before pregnancy or before 20 weeks of pregnancy
Gestational hypertension*: Hypertension first seen after 20 weeks of pregnancy
Preeclampsia*: Gestational hypertension plus abnormalities in at least one body organ system, such as kidney, liver or brain, or blood-clotting factors
Eclampsia*: Seizure (epileptic fit) in a pregnant person with no history of seizure or no known brain injury to explain a seizure. It is usually associated with preeclampsia but may occur without high blood pressure.
HELLP syndrome*: A severe form of preeclampsia with a combination of several abnormalities of blood cells and liver enzymes
*Hypertensive diseases of pregnancy: any of the types above that are marked with an asterisk (*)
Why Did I Get High Blood Pressure?
We do not know all the causes of high blood pressure. Many factors increase the chances of having hypertensive diseases of pregnancy, including:
High-risk factors: Hypertension in a prior pregnancy, twin pregnancy, diabetes, kidney disease and some autoimmune diseases
Moderate-risk factors: First pregnancy, age over 35, obesity, in vitro fertilization, Black ethnicity, family history of hypertension, low income
Only some people with these risk factors get high blood pressure. Some people get high blood pressure even though they don’t have any risk factors.
Management of Hypertensive Diseases of Pregnancy
Management options depend on a careful evaluation of several questions, such as:
What type of hypertension is it? — To determine which type of hypertension is present, your physician will order a urine test to see if your kidneys are leaking protein and blood tests to check your liver and blood cell counts.
Is the condition severe? — Hypertensive diseases are considered “severe” when any of these occurs:
Very high blood pressure (upper number 160 or more or lower number 110 or more)
Eclampsia (seizure)
Very low blood platelets (less than 100,000)
Elevated liver enzyme blood tests (twice as high as normal)
Kidney not functioning well (blood creatinine 1.2 or more)
Fluid in lungs
New onset unexplained severe headache that does not get better with medicine
Disturbances in vision
Is it getting worse, and if so, how fast? — The answer to this question requires blood pressure follow up over hours, days or weeks. Sometimes follow-ups of urine tests and blood tests are needed.
Should the pregnancy be continued or delivered? — The decision to deliver involves a trade-off of risks to the pregnant person versus risks to the baby. Hypertensive diseases of pregnancy usually get worse over time, so the lowest risk for the pregnant person is to deliver as soon as the problem is discovered. Premature delivery carries risks to the baby. These risks are highest at very early gestational ages and gradually decrease as the pregnancy approaches the due date. Timing
of delivery for hypertensive diseases of pregnancy will depend on your circumstances, but will often follow these general guidelines:
37 weeks or more: Delivery is usually recommended
34 weeks or more: Delivery is recommended for severe hypertensive disease
Before 34 weeks: Delivery is recommended for severe hypertensive disease that is getting worse
For chronic hypertension, delivery timing depends on whether your blood pressure is well-controlled and blood pressure medications are being used.
Can hypertensive diseases of pregnancy be treated with medications? — Medications are often used to reduce blood pressure. But lowering the blood pressure does not prevent or treat abnormalities in organs, such as kidneys, liver or brain, or blood clotting. Magnesium helps reduce the chance of a seizure in severe cases. Magnesium does not reduce blood pressure.
Will My Blood Pressure Improve After Pregnancy?
For most people with hypertensive diseases of pregnancy, blood pressure and other organ changes will return to normal within a few weeks after delivery. Some patients will need medication to reduce blood pressure during this time.
For people with chronic hypertension and some with hypertensive diseases of pregnancy, blood pressure remains high and long-term medication is needed to reduce blood pressure.
Even if your blood pressure returns to normal soon after delivery, it may rise again after you get home. For this reason, blood pressure follow up is essential. Even if your blood pressure returns to normal, patients who had high blood pressure during pregnancy, even if it was not severe, have an increased chance of developing heart conditions, stroke, kidney disease, diabetes and other complications in the future, sometimes years or even decades later.
What Follow-Up Is Needed After Delivery?
With severe hypertension, the American College of Obstetricians and Gynecologists recommends that you be seen for a follow-up visit within 72 hours after discharge from the hospital. For non-severe hypertension, follow-up within seven to 10 days is recommended.
Everyone who has had hypertension during pregnancy should establish care with a primary care provider and inform the provider that they have had hypertension during pregnancy. Usually, the primary care provider should screen for risk factors for cardiovascular (heart) disease every year, including checking blood pressure, cholesterol, lipids and a diabetes screen.
Will I Have Hypertensive Disease in Future Pregnancies?
Preeclampsia and gestational hypertension recur in about 30% of cases (one in three). The odds of recurrence are higher if you had a preterm delivery or severe preeclampsia. Low-dose aspirin reduces the odds of recurrence. Ask your provider if you should take aspirin during your next pregnancy.
Which Urgent Warning Signs Need Attention?
High blood pressure is sometimes called a “silent killer” because it may not produce any symptoms. If you are taking your blood pressure at home, notify your provider immediately if you get a value of 160 or higher (upper number) or 110 or higher (lower number).
The following symptoms may indicate severe disease, whether or not blood pressure is high and whether you are still pregnant or have already delivered. Notify your provider right away if you have any of the following symptoms:
Headache that won’t go away or that gets worse over time
Preeclampsia is a disease that occurs during pregnancy or soon after delivery involving high blood
pressure plus other health issues, such as protein in the urine, liver problems or blood clotting
issues. In severe cases, it may cause seizure, stroke, kidney failure or other serious complications. Preeclampsia affects about 4% of all pregnancies (one out of every 25).
What Causes Preeclampsia?
The exact cause of preeclampsia is unknown. However, it is not your fault. For most people diagnosed
with preeclampsia, there was nothing they did to cause it and nothing they should have done to try to
prevent it.
The primary treatment for preeclampsia is delivery. Blood pressure, kidney function and liver function
usually return to normal in the days or weeks following the delivery of your baby.
When Should I Have a Follow-Up Visit After Going Home?
Blood pressure can rise again after you go home from the hospital. For this reason, it is essential to
see your obstetrician within a few days.
The American College of Obstetricians and Gynecologists (ACOG) recommends a follow-up visit:
Within three days of going home, if you had severe high blood pressure
Within seven to 10 days of going home, if you did not have severe high blood pressure
The purpose of the follow-up visit is to review your blood pressure and any other symptoms you might
be having. Medications may be adjusted, and additional follow-up may be suggested during your visit.
This can be a “telemedicine” video visit if you monitor your blood pressure at home.
Are There Warning Signs of Post-Delivery Preeclampsia?
Call your doctor’s office right away or seek emergency care if you have any of the following symptoms
that may signal that preeclampsia has returned:
Severe headache or a headache that doesn’t go away
Blood pressure 160 (upper number) or 110 (lower number) or higher
Will Preeclampsia Happen Again in Future Pregnancies?
Up to one in three women with preeclampsia will get it again during the next pregnancy.
Is There Anything Special I Should Do During My Next Pregnancy?
Current recommendations for future pregnancies in people who have had preeclampsia include:
Low-dose aspirin — Reduces the chance of getting preeclampsia again.
Lab testing to check your kidney and liver functions early in your pregnancy.
Ultrasounds to check the growth of the fetus (unborn baby) during the third trimester (last few
months of pregnancy).
Be alert to warning symptoms that may signal that preeclampsia is developing and discuss these
with your care provider right away or seek urgent medical attention:
Severe or persistent headache
Trouble with vision (blind spots, blurred vision, double vision)
Unexplained pain in your upper belly
Swelling of hands or face
Blood pressure over 140 (upper number) or 90 (lower number) or persistent increase above your normal pressure
Your prenatal care provider may recommend a consultation with a maternal-fetal medicine specialist (high-risk obstetrician) to discuss an individual care plan for you.
Does Preeclampsia Affect My Long-Term Health?
For most people, blood pressure returns to normal and other problems resolve in the days or weeks after delivery.
However, even though it looks like the disease has gone away, people who have had preeclampsia have a higher chance of developing several diseases later in life. These may occur right away, a few years later or even many decades later, including:
High blood pressure
High triglycerides (fat) in the blood
Low HDL levels (good cholesterol)
High blood sugar (prediabetes)
Weight gain (obesity)
It is called metabolic syndrome if you have three or more of these. People with metabolic syndrome are at high risk for diabetes and heart disease.
Healthy lifestyle choices reduce the chances of getting metabolic syndrome:
Maintain healthful diet
Maintain a healthy weight (BMI between 21 and 25)
Moderate exercise 30 minutes five times a week (even light walking is better than nothing!)
Stop smoking or vaping tobacco or nicotine products
ACOG recommends screening yearly for metabolic syndrome for people who have had preeclampsia. This includes checking the following:
Blood pressure
Weight
Lab tests for cholesterol, triglycerides and diabetes
It is important to let your primary care doctor know that you have had preeclampsia, so you receive appropriate screening.
Preterm birth (PTB) is any birth before 37 weeks of pregnancy and occurs in about one in 10
pregnancies in the United States. The underlying cause of most PTBs is unknown. Most PTBs cannot
be prevented.
There are two types of PTB — spontaneous and indicated. Spontaneous PTB results from natural events, including:
When the body naturally goes into labor prematurely
When the amniotic membrane (bag of water) breaks, called rupture of membranes (ROM)
When the cervix dilates silently, called cervical insufficiency
Indicated PTB occurs when the mother or fetus (unborn baby) has a serious health condition that
could be harmful to either of them, such as:
Medical conditions of the mother (severe high blood pressure, diabetes, obesity)
Fetal growth restriction
Placenta previa (the placenta partially or completely covers the cervix opening)
Bleeding from the uterus (womb)
Abnormal fetal heart rate
Prior surgery of the uterus (some types of C-section or fibroid removal)
Certain other reasons
Am I at Risk of Having Another PTB?
If you have had a PTB, there is a chance of another PTB in future pregnancies. Several other
factors may put you at higher risk of having a PTB, such as:
Pregnancy with twins, triplets or more fetuses
Problems with the cervix or uterus
Certain health conditions (high blood pressure, malnutrition, obesity, diabetes, vaginal
bleeding, infection)
Mother is over age 40
Tobacco, drug or alcohol use
Exposure to environmental pollutants
How Can I Reduce My Chances of Another PTB?
Before Pregnancy
There are several steps you can take to improve your overall health that may reduce risks
of PTB, such as:
Wait 18 to 24 months to become pregnant again. Use a reliable form of contraception
(birth control) until at least 18 months after giving birth.
Stop all tobacco products (smoking, vaping, snuff, chewing tobacco).
Stop marijuana use.
Stop illicit drug use.
Aim for a healthy body weight by exercising regularly and eating healthful foods.
Work with your doctor to manage any medical problems, such as diabetes and high blood
pressure, before you get pregnant again.
Ask your doctor if your current medications are safe during pregnancy.
Take a prenatal vitamin every day before and during pregnancy.
Your doctor may recommend a consultation with a maternal-fetal medicine (MFM) specialist to help
you plan for subsequent pregnancies.
During Pregnancy
After a Spontaneous PTB
Two ways to reduce the risks of another PTB after a spontaneous PTB include:
Ultrasounds to check your cervix length. If your cervix is short or showing other changes, your
doctor may recommend specific treatments.
A progesterone supplement (a natural hormone) or similar medication may help reduce the chance
of another PTB.
After an Indicated PTB
Common reasons for an indicated PTB are preeclampsia, high blood pressure and fetal growth
restriction. If you had one of these, you might need:
Low-dose aspirin starting at 12 weeks of pregnancy to reduce the risks of preeclampsia, fetal growth
restriction and spontaneous PTB. Ask your doctor or MFM specialist if you are a good candidate for
low-dose aspirin.
Ultrasound exams during the last few months of pregnancy to check fetal growth.
If you had another indication for PTB, discuss with your doctor
How Does a Preterm Birth Affect My Long-term Health?
Women who have given birth prematurely are at higher risk for certain health problems later in
life, sometimes soon after birth, sometimes many years or even decades later. These problems
are part of “metabolic syndrome,” which includes one or more of the following:
High blood pressure
Heart disease
Stroke
Type 2 diabetes
Excess body fat around the waist
Abnormal cholesterol and triglyceride levels
How Can I Reduce My Risks of Future Health Problems?
Breastfeed as long as you can — Breastfeeding reduces your risk of diabetes, high blood
pressure and heart disease and may help you lose weight after delivery.
Stay active — Exercise moderately 30 minutes a day, several days a week. Even a
30-minute walk can help.
Aim for a healthy body weight by eating a healthful diet and exercising.
Quit using tobacco, vaping products and illicit drugs.
Make sure your primary care provider is aware of your PTB history. Discuss whether you
should have testing every year for blood pressure, diabetes, cholesterol and triglyceride.
If you had a prior preterm birth (PTB), you should see your doctor before your next pregnancy or as early as possible during pregnancy to discuss the best options for your care.
What Is Preterm Birth?
A birth is considered preterm if it is more than three weeks before the due date. Preterm babies may have many types of health problems. PTB can happen for many reasons.
It is helpful to divide PTB into two main types:
Medically indicated PTB is when the doctor starts the birth process (induction of labor or scheduled cesarean) because of issues such as high blood pressure, poor fetal growth, placenta problems or other conditions.
Spontaneous PTB is when the birth process starts naturally, such as preterm labor, rupture of the membranes (ROM) or cervix opening (dilating) without labor.
The following information focuses primarily on spontaneous PTB.
If I Had a Previous PTB, Will It Happen Again?
If your prior PTB was medically indicated, the odds of a repeat PTB depend on the reason for the PTB. Your doctor will review your history, estimate the odds of a repeat PTB and discuss whether any treatments will reduce the odds.
With a prior spontaneous PTB, the odds of a repeat PTB are about 1 in 3 (30%) overall.
Many factors increase the risk, including:
Prior PTB very early in pregnancy
Multi-fetal pregnancy (twins, triplets, etc.) in current pregnancy
Abnormalities of the uterus, such as large fibroids
Abnormalities of the cervix, such as lacerations or insufficiency
Health conditions like high blood pressure, diabetes, kidney disease and autoimmune disorders
Uterus, vagina, bladder, kidneys or systemic (whole-body) infections
Smoking, vaping, non-prescription drug use and alcohol consumption
Inadequate intake of essential nutrients, including folic acid and iron
A short interval between pregnancies
Age under 18 years or over 35 years
Low income, which is associated with limited access to health care, financial stress, poor living conditions and poor nutrition
Black, Native American and Alaska Native race, due to inequities in income, racism and other social drivers of health
What Can I Do To Lower the Odds of a Repeat Spontaneous PTB?
You can take several general steps to decrease the chance of another PTB, including:
Prioritizing prenatal care: Attend all prenatal appointments.
Maintaining a healthy lifestyle: Maintain a balanced diet, exercise regularly (with your doctor’s approval) and avoid smoking, vaping, alcohol and non-prescription drug use.
Managing chronic conditions: Work with your doctor to manage blood pressure, diabetes and other health problems.
Minimizing stress: Use relaxation techniques and social support. Seek professional help if needed.
Asking questions: Don’t hesitate to ask your doctor if you have questions or concerns. Be sure to report any symptoms such as cramping, pain, fever, bleeding and unusual discharge.
While these steps may decrease the odds of a repeat PTB, they will not eliminate the risk.
Do Doctors Recommend Other Steps to Lower the Odds of a Repeat Spontaneous PTB?
Yes, other recommendations include:
Cervical length screening: The cervix is the passageway between the uterus (womb) and the vagina. The cervix is measured by ultrasound during the middle part of pregnancy. If you had a prior spontaneous PTB, this ultrasound may be repeated several times. If the cervix is short or open, your doctor may recommend other treatments such as progesterone or cerclage.
Progesterone: The placenta makes this natural hormone during pregnancy. Adding extra progesterone may sometimes reduce the risk of a repeat PTB.
Vaginal progesterone may be given for a short cervix. This decreases the odds of PTB almost by half and may be considered an alternative to cerclage.
Vaginal progesterone can also be given as a preventative based on a history of prior PTB. There is evidence favoring this, but benefits have yet to be shown consistently.
Injectable hydroxyprogesterone caproate is no longer available. The FDA withdrew approval for this medication after a large clinical trial that did not show any benefits.
Cerclage: This procedure places a stitch (suture) around the cervix to help it stay closed. The stitch placement is a surgery performed in a hospital operating room.
A cerclage is placed as a preventative based on a history of prior PTB. This approach may be favored instead of having multiple ultrasounds to check the cervix length.
Cerclage can also be placed for treatment of a short cervix. In this setting, cerclage reduces the odds of a repeat PTB almost by half. Vaginal progesterone may be used instead of or in addition to cerclage.
While taking these steps may minimize the reoccurrence of a PTB, they will not eliminate the risk. Your doctor will discuss the pros and cons of the different approaches. After this discussion, you and your doctor will decide which steps are best for you.
Are There Long-Term Health Concerns Associated With PTB?
People who have had a PTB have higher odds of high blood pressure, high cholesterol, diabetes, heart disease or stroke than people who have given birth without PTB. This increase in risk is found for those with both medically indicated and spontaneous PTB.
Because of these risks, it is recommended that you establish ongoing care with a primary care provider (such as an internal medicine specialist or family medicine doctor) and be evaluated every year for:
High blood pressure
Weight management
Dietary review
Cholesterol and triglyceride screening blood tests
Diabetes (A1c) screening blood test
Be sure to tell your primary care provider about your history of PTB.
Understanding Short Cervix, Preterm Birth and Progesterone
The cervix is the passageway between the uterus (womb) and the vagina. When the cervix stays closed, it prevents the baby from being born. Usually, the cervix stays long and closed until the due date is near. The length of a normal cervix is 25 to 40 millimeters (about 1 to 2 inches). The cervix opens during childbirth (labor), allowing the baby to be born.
What Is a Short Cervix?
A cervix is considered short if it measures less than 25 mm (1 inch). If the cervix is short in the middle part of pregnancy, it might open and result in preterm birth. A short cervix does not always cause preterm birth, but it increases the odds. The good news is there are ways to reduce the odds of preterm birth.
What Is Preterm Birth?
A birth is considered preterm if it is more than three weeks before the due date. Preterm babies may have many types of health problems. Preterm birth can happen for many reasons, and cervical shortening is one of them.
Can Preterm Birth Be Prevented If I Have a Short Cervix?
Two treatments reduce the odds of preterm birth in women with a short cervix in the middle of pregnancy: progesterone and cerclage.
What Is Progesterone?
Progesterone is a natural hormone made by the placenta during pregnancy. With a short cervix, extra progesterone reduces the chance of preterm birth by half, but it does not eliminate the risk entirely.
Progesterone is prescribed as a capsule or a gel and inserted into the vagina each night. The most common side effect is a scant amount of oily discharge. Vaginal progesterone is considered safe for pregnancy and has no known adverse effects on the baby. Some forms of progesterone contain peanut oil. If you have a peanut allergy, you should use a form that does not contain peanut oil.
What Is Cerclage?
Cerclage is a stitch (suture) placed around the cervix to help it stay closed. The stitch placement is a minor surgery performed in a hospital operating room. If the cervix is very short or the patient has had a prior preterm birth, cerclage reduces the risk of preterm birth by about half. It does not eliminate the risk of preterm birth.
Which Is Better – Progesterone or Cerclage?
Both treatments have pros and cons. Both may reduce the risk of preterm birth, but neither is 100% effective. Your doctor will discuss the advantages and disadvantages of the two treatments. Factors that may affect the choice include:
Shortness of the cervix
How far along the pregnancy is
History of prior preterm birth
After this discussion, you and your doctor will decide which approach is better for you.
Is There Anything Else I Can Do to Lower the Risk of Preterm Birth?
Regular check-ups: Keep all your appointments for regular prenatal visits and ultrasounds.
Stay healthy: Eat well and get enough rest. Do not smoke, vape or take non-prescription drugs.
Minimize stress: Use relaxation techniques and social support. Seek professional support if needed.
Manage chronic conditions: Work with your doctor to manage diabetes, blood pressure, etc.
Exercise: If you have a regular exercise program, it may be okay to continue exercising even if the cervix is short or if you have a cerclage. Discuss with your doctor whether you should modify your activity level.
Ask questions: Don’t hesitate to ask your doctor if you have questions or concerns.
Be sure to report any symptoms such as cramping, pain, fever, bleeding and unusual discharge.
Progesterone is a naturally occurring hormone made by the ovaries and the placenta. During pregnancy, progesterone may help prevent preterm birth by decreasing contractions of the uterus, preventing opening of the cervix and decreasing inflammation.
Why Is Progesterone Inserted Into the Vagina Rather Than Swallowed?
Progesterone is believed that the medicine is most effective for a short cervix if it is inserted into the vagina, so most of the medicine goes directly to the cervix.
What Is Prometrium?
Prometrium is the brand name of a capsule containing natural progesterone and a small amount of peanut oil. For a short cervix, your doctor may prescribe a 200 mg capsule. There are several FDA-approved generic forms that can be substituted for the brand name version. The generics should be identical to Prometrium and are usually less expensive. Your pharmacist can make this substitution unless “dispense as written” is indicated on the prescription.
Where Do I Get the Medicine?
Many local pharmacies keep Prometrium in stock. Others may need to order it, which can take a few days. We would like you to start the medicine as soon as possible, so we suggest you call local pharmacies and find one that has it in stock before you take the prescription to be filled.
When Do I Take the Medicine? When Should I Start?
Once a day, at bedtime. Once you have the medicine, you should start it that night.
How Long Should I Use It?
You should continue taking progesterone until you reach 37 weeks of pregnancy (i.e., three weeks before your due date). For example, if your due date is a Monday, your last dose of progesterone will be on a Sunday night, three weeks before your due date.
How Do I Insert the Progesterone Capsule?
Insert the medication at bedtime.
Wash your hands with soap and water.
Gently insert the capsule into the vagina with your finger and push it into the vagina as far as it will comfortably go. You may insert the capsule while lying down, sitting or standing—whatever you find easiest. Lying down after application will reduce leakage of the medication.
The capsule contains peanut oil, so when it dissolves, you may have a small amount of oily discharge. We recommend using a panty liner or sanitary pad to prevent the oil from getting on your bedclothes or sheets. Do not use a tampon.
What If I Miss a Dose?
If you miss a dose of progesterone, take it as soon as you remember, unless it is time for the next dose, in which case skip the missed dose. Do not take a double dose.
Are There Potential Side Effects?
The most common side effect is a scant amount of oily discharge, which is the release of the oil in the capsule. This is easily managed by wearing a panty liner. Progesterone has no known adverse effects on the developing fetus. In fact, progesterone is necessary for a healthy pregnancy. The placenta makes large amounts of progesterone. The added progesterone inserted vaginally is a supplement to the progesterone already present in all pregnancies. The following side effects have been reported when progesterone is given to women who are not pregnant: nausea, bloating, breast tenderness, headache, change in vaginal discharge, mood swings, blurred vision, dizziness or drowsiness may occur. Many pregnant women already experience these symptoms, and this may be because of the progesterone made by the placenta. We do not expect that these will increase significantly by adding a small amount of added progesterone in the vaginal capsule. However, if any of these effects persist or worsen, notify your doctor.
Are There Any Precautions?
Prometrium contains peanut oil. Do NOT take this medication if you have a peanut allergy.
If you have had a previous allergic reaction to Prometrium or other formulations of vaginal progesterone, you should NOT take this medication. If you have a history of any of the following problems, speak to your doctor before taking this medication:
history of blood clots
history of hypertension or heart disease
history of seizures
history of depression
history of lupus
liver or kidney disease
cancer of the breast or other female organs
vaginal bleeding of unknown cause
recent stroke or heart attack (within 1 year)
This drug may make you dizzy or drowsy. Do not drive, use machinery or do any activity that requires alertness until you are sure you can perform such activities safely. Do not stop medication without discussing it with your doctor ahead of time. Do not smoke. Smoking combined with this medication may increase your risk for strokes, blood clots, high blood pressure and heart attacks. This medication may cause blotchy, dark areas on your skin (melasma). Sunlight may worsen this effect. Avoid prolonged sun exposure, tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors.
When Should I Contact My Doctor While Taking Progesterone?
If you experience any of the following, please contact your doctor.
Pain associated with redness and/or swelling in one or both legs
Persistent or worsening feelings of depression or mood swings
A discharge that is unusual in color, consistency or amount
A burning or itching sensation in the vaginal area
A foul odor associated with vaginal discharge
Shortness of breath
Vaginal bleeding
Preterm labor symptoms, including:
Contractions
Leaking fluid from your vagina
Pelvic pressure
Low, dull backache
Cramps that feel like your period
Abdominal cramps with or without diarrhea
How do I store progesterone, and what do I do with any leftover medication after delivery?
Store at room temperature (77o F or 25o C) away from light and moisture. Keep all medicines away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about safely discarding your product.
Ultrasound is a method to get pictures or videos of the fetus (unborn baby). There are many reasons to perform an ultrasound, including to:
Help determine the due date
Find out whether there is only one fetus or multiples (e.g., twins or triplets)
Determine if the fetus is growing normally
Identify birth defects or other problems
Ultrasound uses sound waves to generate the images, not X-rays or radiation. It is painless and
safe for both the mother and fetus.
Special Ultrasound Exams
Our maternal-fetal medicine physicians have special training and certification to perform
certain types of ultrasound that may not be available from a radiology service or a general
obstetrician. These exams are performed in certain situations, not in every pregnancy. Special
exams include:
Biophysical profile: An assessment of fetal movements and amniotic fluid (the liquid
surrounding the fetus) to check fetal well-being.
Doppler: A method of measuring blood flow through certain blood vessels, including the
umbilical cord, arteries in the fetal brain, veins in the fetal liver and arteries to the mother’s
uterus. Blood flow measurements help to check on fetal well-being.
Fetal echocardiogram: A detailed exam of the fetal heart to look for heart defects.
3-D ultrasound: Still pictures that appear 3-dimensional are used to get further detail of certain
types of birth defects.
4-D ultrasound: Videos that appear 3-dimensional are used to get further detail of certain
types of birth defects.
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